The functional meaning of the Notch signaling cascade for neurodegeneration: a translational approach. KU Leuven
Amyotrophic lateral sclerosis (ALS) is a devastating late-onset neurodegenerative disease that mainly affects motor neurons. In this disease, motor neuron degeneration is accompanied and aggravated by oligodendroglial pathology and the presence of reactive astrocytes and microglia.
In this PhD thesis, the role of the Notch signaling pathway in ALS was investigated, as this pathway is implicated in several processes that might contribute ...