Publications
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The long noncoding RNA Neat1 is required for mammary gland development and lactation KU Leuven
The lncRNA Neat1 is an essential architectural component of paraspeckle nuclear bodies. Although cell-based studies identified Neat1-paraspeckles as key regulators of gene expression through retention of hyperdited mRNAs and/or transcription factors, it is unclear under which specific physiological conditions paraspeckles are formed in vivo and whether they have any biological relevance. Herein, we show that paraspeckles are assembled in luminal ...
Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia Ghent University
Eradication of neuroblastoma by suppressing the expression of a single long noncoding RNA Ghent University
The long non‐coding RNA LINDA restrains cellular collapse following DNA damage in Arabidopsis thaliana Ghent University Flanders Institute for Biotechnology
The genomic integrity of every organism is endangered by various intrinsic and extrinsic stresses. To maintain genomic integrity, a sophisticated DNA damage response (DDR) network is activated rapidly after DNA damage. Notably, the fundamental DDR mechanisms are conserved in eukaryotes. However, knowledge about many regulatory aspects of the plant DDR is still limited. Important, yet little understood, regulatory factors of the DDR are the long ...
Protocol to analyze circulating small non-coding RNAs by high-throughput RNA sequencing from human plasma samples KU Leuven
The identification and validation of circulating small non-coding RNA (sncRNA) as biomarkers for disease diagnosis, staging, and response to novel therapies is still a compelling challenge. Pre-analytical variables, such as storage temperature or blood hemolysis, and different analytical approaches affect sncRNA stability, detection, and expression, resulting in discrepancies among studies. Here, we report a systematic standardized protocol to ...