Functional biomarkers of cartilage mechanics in osteoarthritis – an MRI-based, multi-scale adaptive modeling framework to bridge from in vitro destructive testing to in vivo clinical applications KU Leuven
Osteoarthritis (OA) is the most common joint disease and significantly impairs the quality of life of those affected by this painful progressive disease. As a consequence, the economic burden is high for both the individual and society. Today, no successful preventive interventions have been identified yet. It is however known that cartilage degeneration and loss of its unique mechanical properties is the hallmark of OA and that mechanical ...