Publications
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MODS assay for the diagnosis of TB [letter] Institute of Tropical Medicine
Evaluation of colorimetric methods using nicotinamide for rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis Ghent University
The direct detection of pyrazinamide resistance in Mycobacterium tuberculosis is sufficiently difficult that many laboratories do not attempt it. Most pyrazinamide resistance is caused by mutations that inactivate the pyrazinamidase enzyme needed to convert the prodrug pyrazinamide to its active form. We evaluated two newer and simpler methods to assess pyrazinamidase activity, the nitrate reductase and malachite green microtube assays, using ...
Evaluation of the TB Ag MPT64 rapid test for the identification of Mycobacterium tuberculosis complex Institute of Tropical Medicine
Contributions to the diagnosis of pirazinamide resistance in Mycobacterium tuberculosis Institute of Tropical Medicine
Biomarkers and diagnostics for tuberculosis [author's reply] Institute of Tropical Medicine
Rapid alternative methods for detection of rifampicin resistance in Mycobacterium tuberculosis Institute of Tropical Medicine
Diagnosis of drug-resistant tuberculosis: reliability and rapidity of detection Ghent University
With the emergence of multidrug-resistant tuberculosis (MDR-TB), the need for rapid drug susceptibility testing (DST) is felt globally. National tuberculosis control programmes (NTPs) may find it hard to choose from the bewildering variety of rapid tests. We give an overview of the most important methods, discussing their merits and shortcomings, emphasising techniques that offer an alternative to the commercial systems and genotypic tests. ...
Evaluation of colorimetric methods using nicotinamide for rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis Institute of Tropical Medicine
The direct detection of pyrazinamide resistance in Mycobacterium tuberculosis is sufficiently difficult so that many laboratories don't attempt it. Most pyrazinamide resistance is caused by mutations that inactivate the pyrazinamidase enzyme needed to convert the prodrug pyrazinamide to its active form. We evaluated two newer and simpler methods to assess pyrazinamidase activity - the nitrate reductase and malachite green microtube assays - ...