Projects
MOLECULAR DIAGNOSTICS IN AUTISM SPECTRUM DISORDER: NEXT GENERATION SEQUENCING AND FACIAL PHENOTYPING IN MEDICAL GENETICS KU Leuven
Despite considerable progress in the genetics of autism spectrum disorder (ASD) in the past decade, molecular diagnostics for patients with ASD remains a great challenge due to the complex genetic architecture of ASD. In clinical genetics, an etiological distinction is usually made between ASD patients with Mendelian causes (i.e. driven by a highly penetrant rare variant) and patients with multifactorial causes (i.e. driven by many genetic ...
RNA interference identification of relevant novel mutations detected by next generation sequencing in T-cell acute lymphoblastic leukemia. KU Leuven
Accelerate and automate the "next generation sequencing" workflow Hasselt University
Next generation sequencing technology opening new frontiers in biological and medical research. University of Antwerp
Exploiting Next Generation Sequencing to identify key-players in Arabiodopsis thaliana hypocotyl expansion. University of Antwerp
Population-based next generation sequencing to elucidate the complex genetics of Alzheimer dementia. University of Antwerp
Inherited predisposition for breast cancer in the next generation sequencing era: evaluation of the role of genes involved in homologous recombination and G2/M checkpoint control and decelopment of a functional assay. Ghent University
In less than 20% of the familial breast cancers a germline mutation in the major breast cancer genes BRCA involved in hte same pathway by a next generation sequencing approach. Furthermore, we will develop a functional assay to elucidate the role of variants of unknown significance.
Next generation sequencing in molecular genetics for hereditary breast cancer, an emerging new strategy Ghent University
Germline BRCA1&2 mutations do not explain a large proportion of the families with hereditary breast cancer. This bilateral research project aims to gain insight in the role of ATM, BRIP1, CHEK2 and PALB2 mutations in Flemish and Québec breast cancer families using the next generation sequencing (NGS) technology. The expertise of both research groups in complementary: the Flemish group will be strongly involved in the development of an ...