Projects
On the long-term footprint of pediatric critical illness and how this is affected by acute macronutrient restriction KU Leuven
Children are admitted to the pediatric intensive care unit (PICU) when they acutely need vital organ support to avoid imminent death. Although most of the children need intensive care for only a few days and most of them seemingly recover well from the acute insult, many of them are confronted with long-term consequences after critical illness as observed years after hospital discharge. This legacy, which remains largely unexplained, broadly ...
Molecular neurobiology of aging. KU Leuven
Aging is the primary risk factor for many human pathologies such as cardiovascular diseases, cancer, diabetes and neurodegenerative disorders. Therefore, societal aging comes with an emotional and financial burden of age−related health issues and diseases, most of which go without a cure. While vast amounts of money are being spent on the study of aging−related diseases, surprisingly little investments have been made to sort out the ...
Understanding and preventing the impact of endocrine disruptors on the hypothalamus-pituitary axis in sensitive populations KU Leuven
Exposure to multiple endocrine disrupting chemicals (EDC) is an environmental insult that interferes with the development and function of the endocrine system, governed by the hypothalamus-pituitary (HP) axis. This interaction is specially concerning in developmental stages of life, such as the perinatal period and puberty. Despite the current body of knowledge on EDC actions on the endocrine system, a comprehensive, holistic understanding of ...