Projects
Role of metals and metal containing biomolecules in neurodegenerative diseases such as Alzheimer's disease Ghent University
This European project aims to overcome the limitations caused by a lack of reference measurement procedures for established Alzheimer's disease (AD) biomarkers in cerebrospinal fluid (CSF), while also introducing reference measurement procedures for potential new blood-based AD biomarkers, such as metals and metalloproteins. The traceability of the provided reference measurement procedures will provide comparability between laboratories.
Dissecting the link between astrocyte diversity and PD risk” to investigate how neurodegenerative diseases, including Parkinson’s disease, intersect with regional aspects of astrocyte identity Flanders Institute for Biotechnology
Genetic profiling of patients with neurodegenerative disease to identify markers for (early) diagnosis and disease progression KU Leuven
The role of protein aggregate maturation in Alzheimer's disease and other neurodegenerative disorders and its potential for disease monitoring and differential diagnosis. KU Leuven
This project aims at identifying changes in the composition of Alzheimer’s disease (AD)-related protein aggregates throughout preclinical and clinical stages of the disease. Moreover, we want to find out whether such “maturation changes” can be clinically detected by specific biomarkers or may represent potential therapeutic targets. To address these aims we analyze human brain tissue samples from non-AD, preclinical AD, and symptomatic AD ...
The eye as a window to the brain - a quest for retinal biomarkers in neurodegenerative disease KU Leuven
Because of a shared ontogenic origin, the retina displays similarities to the brain and spinal cord in terms of anatomy, functionality, response to insult, and immunology. Hence, the retina can be approached as an integral part of the central nervous system. The occurrence of ocular manifestations in several neurodegenerative pathologies, such as Alzheimer's disease disease, accentuates the strong relationship between eye and brain. ...
Genome-wide genotype-phenotype associations in Drosophila for neurodegenerative disease pathway and drug target discovery. KU Leuven
The increase in life expectancy in the Western world has seen a growing number of individuals suffering from neurodegenerative disorders. Many of these disorders are associated with the accumulation of toxic protein species, such as amyloid beta (aß) peptides in Alzheimer’s disease (AD), microtubule-binding Tau in AD and frontotemporal lobe degeneration (FTLD), a-synuclein in Parkinson’s disease (PD), and TDP-43 in amyotrophic lateral ...