Projects
Mapping amyloid-induced neurodegeneration in the gut using MALDI imaging. University of Antwerp
ADME study of lead ferroptosis inhibitor which blocks organ injury and neurodegeneration in mice. University of Antwerp
Targeting the immunodeficiency and neurodegeneration in a hereditary sensory neuropathy (HSAN type I) associated with dysfunction of the serine palmitoyltransferase. University of Antwerp
Development of next-generation 3D brain organoids for the study and modulation of immunemediated neurodegeneration in cerebrovascular disease. University of Antwerp
The hAPP KM670/671NL x TDO knockout mouse model: genetic interference with tryptophan metabolism and proteome ageing in neurodegeneration. University of Antwerp
Cell biology of the endo-/lysosomal proteostasis in cancer and neurodegeneration (LYSOCaN). KU Leuven
Can induced pluripotent stem cells from frontotemporal dementia be used to characterize mechanisms underlying progranulin haploinsufficiency mediated neurodegeneration? KU Leuven
Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral changes and language difficulties. Unlike other forms of dementia, FTD generally affects younger people and is heritable in many cases, with mutations in three genes (GRN, MAPT and C9orf72) explaining the majority of genetic cases. Autosomal dominant loss-of-function mutations in progranulin (GRN) induce haploinsufficiency ...
Translational study on dopaminergic modulation in normal visual cortex and neurodegeneration. KU Leuven
We recently observed a remarkably robust but surprising effect in early visual cortex of monkeys in the absence of a visual stimulus. We found that rewards without visual stimulation selectively decrease fMRI activity within the representation of a stimulus that was paired with the reward during entirely different trials. In particular, we found that these reward signals can modulate (reduce) activity in visual cortex in a spatially-specific ...