From Sheet to tube: Bioengineered Models of Neural Tube Defects KU Leuven
The neural tube, the precursor structure of the central nervous
system, forms from an initially-flat neuroepithelium, termed neural
plate, that folds and creates a tubular architecture. Progenitor cells
differentiate into distinct neural types and organize in discrete
domains as the neural tube bends. Neural tube formation generates
spatially heterogeneous stresses on progenitor cells, influencing
neural fate ...