Deciphering enhancer logic of cell fate decisions during human neural tube and neural crest development, using single-cell multi-omics and machine learning. KU Leuven
Precise, robust and evolutionary conserved mechanisms underlie the ontogeny of cellular identities. Enhancers play a major role in this, by regulating the expression of key factors involved in cell fate decisions in a precise temporal (i.e. at a specific point of time) and spatial (i.e. in specific cell types) manner. The properties of enhancers have been vastly documented, still the fundamental molecular mechanisms (i.e. enhancer logic) ...