Acoustic modulation and localization of nanodroplet vaporization for in vivo proton range verification and dosimetry KU Leuven
Physics, Kulak Kortrijk Campus, Laboratory of Experimental Radiotherapy, Cardiovascular Imaging and Dynamics
The ability of proton therapy to better conform the dose to the tumor is hindered by range uncertainties, forcing clinicians to adopt substantial safety margins. Therefore, in vivo range verification methods are sought. Recently, we showed that injectable nanodroplets can vaporize into microbubbles when exposed to proton radiation. The ultrasound contrast could be related to the proton range with sub-millimeter reproducibility, opening the door ...