Role of NRas ubiquitination in control of melanoma development and progression. KU Leuven
Melanoma is one of the most aggressive skin cancers. The 15–20% of all melanomas harbors activating NRas mutations. At present, little progress has been made in developing targeted therapy strategies for NRas mutant melanoma, thus a better understanding of the Ras pathway is an urgent need for establishing new treatment strategies. We and others have recently demonstrated that ubiquitination of the Ras family members dramatically affects ...