Projects
Functions of NIPP1 in keratinocyte biology and cutaneous wound repair. KU Leuven
The skin forms a protective barrier over the body. The outer skin layer or epidermis mainly consists of keratinocytes that originate from stem cells in the basal layer or the hair shaft bulge. Keratinocytes gradually move up to the surface of the skin, a process that is accompanied by a step-wise differentiation and eventually apoptosis. When damaged, the skin shows a remarkable ability to heal. An important step of the wound healing process ...
Interference of protein phosphatase PP1 with the DNA-repair capacity KU Leuven
Cells have evolved elaborate sensing and repair mechanisms to deal with various types of DNA damage. We have found that the deletion of NIPP1, a substrate-targeting subunit of protein phosphatase PP1, dramatically increases the DNA-repair capacity. Conversely, the overexpression of PP1-NIPP1 in human cells induces numerous DNA lesions. Here, we propose to study the molecular mechanism(s) by which PP1-NIPP1 reduces the DNA-repair capacity and ...