Xylo- and lyxo-type phosphonate nucleic acids: Synthesis and structural analysis KU Leuven
The exploration of the chemical space of nucleic acids is important to identify modified structural analogues with desirable properties for applications in therapy and synthetic biology. Diastereoisomeric DNA and RNA analogues such as deoxyxylo- and xylonucleic acids (dXyloNA and XyloNA) have been demonstrated to be strong-self pairing systems with a flexible backbone that can adopt unique helical geometries, which might play a role in their ...