Combined NMR and ab initio analysis of new fluorinated prolines for their application as structural modulators and NMR probes in disordered proline-rich peptide sequences Ghent University
Disordered proline-rich proteins play an important role in biology, as they are often involved in protein-protein interactions that mediate cell signalling or gene regulation. Using NMR spectroscopy to investigate them is obstructed by the lack of an amide proton in Pro residues and the low resolution between resonances of different residues. This project proposes introducing various fluorinated prolines (FPro) in proline-rich or oligoproline ...