Projects
Understanding and modulating the pro-inflammatory activity of lipid nanoparticles (LNP) in the COVID-19 mRNA vaccines: towards the development of more effective LNP formulations. Ghent University
The lipid nanoparticle (LNP) technology has enabled the clinical translation of RNA therapeutics, and in particular the role played by the LNPs in today's success story with the mRNA vaccines against COVID-19 has become a very hot topic. The idea that the LNPs do not only work as delivery vehicle, but that they are also the key mediator of the pro-inflammatory activity and associated adverse effects of these mRNA vaccines, is a recent lead of ...
Wastewater treatment using microalgae: optimizing removal of P from wastewaters with a low total N:P ratio. KU Leuven
Phosphorus (P) is an essential element to sustain the global food and feed production. Large amounts of phosphate ores are extracted for the production of fertilizers. The recent global P crisis increased the awareness to use this natural resource in a sustainable way and to increase recycling. A significant part of the global annual P flux ends up in wastewater. Wastewaters are often treated using energy or chemical intensive technologies to ...
NIP Fondatie - Lord Nisse: expert advice vegetation development Ghent University
Within the nature development (NIP) Fondatie-Heernisse viewed what the potential for vegetation development of species-rich nature (blue grassland, marsh marigold grasslands, ...) on former farmland. The current to be enrichment by nutrients and the hydrology placed in detail in a map, and take appropriate remedial action (excavating, uitmijnen of phosphorus, mowing) are discussed.
Supporting the implementation of a bilingual Belgian Thesaurus (Fr / Nl), the ICPC-2 / ICD-10 system, called 3BT, the software for managing medical records related to homologation procedure Ghent University
Supporting the implementation of a bilingual Belgian Thesaurus (Fr / Nl), the ICPC-2 / ICD-10 system, called 3BT, the software for managing medical records related to homologation procedure. The context of this work is the participation of Belgium in the European work on e-health. 3BT thus a Belgian instrument to be included in the work of Estehr. a bilingual version of the Thesaurus was made in January 2008; divided since February 2008 in ...
Monitoring and controlling solid form of APIs crystallized from supramolecular gels by means of NLO techniques KU Leuven
In this project, we will apply harmonic light scattering (HLS) and microscopy as an accessible alternative optical technique to measure the supramolecular gel mediated crystallization of amino acids. For these active pharmaceutical ingredients (API), polarized SHG microscopy has been used to discriminate their polymorphic forms and chirality, to study their growth kinetics. However, the direct detection of nucleation has hitherto stayed out ...
Accurate 3D indoor position estimation by means of sensor fusing UWB and VLP signals KU Leuven
Studying axonal transport and neuronal function using NLO and superresolution microscopy KU Leuven
Neurons critically rely on active transport of mitochondria to match energy production and Ca2+ buffering to local demand. Their complex morphology renders them extremely sensitive even to subtle defects in axonal transport. Consequently, defective mitochondrial trafficking is involved in a number of neurological and neurodegenerative diseases. In this project we aim to advance our fundamental understanding of this transport using state of ...
Confocal and multiphoton laser scanning microscope LSM 710, configuration 2 NLO. KU Leuven
A multiphoton laser scanning microscope enables to obtain high-resolution optical images of fluorescently labeled cells, tissues or small organisms and 3D-reconstructions of complex samples. Furthermore, it allows to follow physiological processes in real-time via time-lapse imaging.
FDA approved NP cellular hitchhiking system for targeted combination therapy and diagnosis in glioblastoma KU Leuven
Glioblastoma (GBM) is the most common type of primary malignant brain tumor. It remains an incurable tumor with a median survival rate of only 15 to 17 months. The standard treatment of GBM is surgical resection followed by radiotherapy and concomitant adjuvant temozolomide. Despite maximal initial therapy, tumors invariably recur. Unfortunately, no significant changes have been accomplished in the treatment protocols of GBM in the last 15 ...