Molecular and functional characterization of MALT1-proteolytic activity in NF-kB activation and lymphoma development Ghent University
Inappropriate NF-kB signaling plays an important role in the initiation and progression of different cancers. MALT1 lymphoma and certain Diffuse Large B-cell lymphomas (DLBCL) are associated with genetic abnormalities in CARD11, BCL10 or MALT1, all resulting in constitutive MALT1-mediated NF-kB activation. CARD11, BCL10 and MALT1 are critical components in antigen receptor induced signalling to NF-xB. Recently, we found that MALT1 has ...