Investigation of Heterotypic Interactions of TDP-43 Aggregation in Neurodegeneration KU Leuven
Oligomerization and accumulation of misfolded proteins in different types of brain cells are one of the most common hallmarks of neurodegenerative diseases, including Alzheimer’s, Parkinson diseases, Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD).Aggregates formed by misfolding of proteins involved in neurodegeneration have a common cross-β structure called amyloid, which is stabilized by specific segments, known as ...