1 - 10 of 45 results
Human and murine macrophages with a stable alternative activation as a therapeutic tool to promote neuroregeneration. University of Antwerp
Mast cell proteases as modulators of the glial scar to promote neuroregeneration after trauma. Hasselt University
Xenotransplantation of iPSC derived microglia to decipher the impact of Progranulin in neuroinflammation and neurodegeneration. University of Antwerp
MACSiMiSE-BRAIN: Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration Hasselt University
MACSiMiSE-BRAIN: Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration University of Antwerp
Investigating the role of tau aggregates in neurodegeneration KU Leuven
The PhD project investigates the role of tau aggregates in neurodegeneration and is part of a wider project that focusses on the discovery of novel monoclonal antibodies that can neutralize tau toxicity and spreading. Tau is the main component of the neurofibrillary tangles that are a hallmark of AD along with Alzheimer beta plaques, and a paradigm of intracellular aggregation. In the etiology of AD, the Abeta aggregation and the abnormal ...
The role of the peripheral immune system on neurodegeneration and neuroinflammation in rodent models for Parkinson’s disease KU Leuven
Parkinson’s disease (PD) is the most common neurodegenerative motor disorder. No therapy can cure, stop or slow down the progression of the disease, as only symptomatic treatment strategies are available. Identifying pathogenic mechanisms underlying neurodegeneration will therefore be essential to develop a disease-modifying drug. PD is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and the ...
The lysosomal exonuclease PLD3 as an endolysosomal flux regulator: impact on neuronal homeostasis and relevance in neurodegeneration. KU Leuven
Late-onset Alzheimer’s disease (LOAD) is characterized by an unbalanced proteostasis. Dysfunctions in endolysomal transport and degradation kinetics arise at early preclinical stages and progressively worsen. Among the known LOAD risk factors, I focus on phospholipase D (PLD)-3. PLD3 is selectively expressed in neurons where it resides in late endosomes and lysosomes. It is an aspecific member of the PLD family, being an exonuclease that ...