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Human and murine macrophages with a stable alternative activation as a therapeutic tool to promote neuroregeneration. Hasselt University

Worldwide, spinal cord injuries (SCI) are a major cause of morbidity, mortality and reduced quality of life. Until now no regenerative therapy for SCI is available and standard care of SCI patients includes primarily the administration of immunosuppressant drugs and rehabilitation. Thus, new therapeutic strategies are desperately needed. After SCI, pro-inflammatory macrophages dominate the spinal cord and exert detrimental effects by ...

Human and murine macrophages with a stable alternative activation as a therapeutic tool to promote neuroregeneration. University of Antwerp

Peter Ponsaerts

Laboratory for Experimental Hematology (LEH), Vaccine & Infectious Disease Institute (VAXINFECTIO)

Mast cell proteases as modulators of the glial scar to promote neuroregeneration after trauma. Hasselt University

Sven HENDRIX

Morphology

Axon regeneration after trauma in the mammalian adult central nervous system (CNS) is restricted due to numerous factors, such as the lack of growth-promoting factors, the low intrinsic capacity of neurons to survive from damage and, most importantly, the presence of growth-inhibitory factors. The most potent inhibitory components in the damaged CNS are molecules of the extracellular matrix (ECM), such as chondroitin sulphate proteoglycans ...

Xenotransplantation of iPSC derived microglia to decipher the impact of Progranulin in neuroinflammation and neurodegeneration. University of Antwerp

Renzo Mancuso

VIB CMN - Microglia and Inflammation in Neurological Disorders (MIND) lab

Frontotemporal dementia (FTD) is a chronic neurodegenerative disease and is the second most common form of dementia worldwide. FTD is characterized by the build up of abnormal proteins inside nerve cells including TAU, FUS or TDP-43. FTD is accompanied by changes in the immune cells of the brain, the microglia. This inflammation in the brain is referred to as neuroinflammation, which may be a simple consequence of damage to nerve cells or may ...

MACSiMiSE-BRAIN: Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration Hasselt University

Immunology & Infection, Rehabilitation Research Center

Multiple Sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease leading to focal and diffuse damage of myelin sheath and axons in the central nervous system (CNS). Pathophysiologically, the adaptive and innate immune system are involved in the inflammatory process, while mitochondrial dysfunction, oxidative stress and failure of remyelination are the main mechanisms in chronic neurodegeneration. Despite currently ...

MACSiMiSE-BRAIN: Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration University of Antwerp

Lander Willem, Joke Bilcke

Primary and interdisciplinary care Antwerp (ELIZA), Centre for Health Economics Research and Modelling of Infectious Diseases (CHERMID)

Investigating the role of tau aggregates in neurodegeneration KU Leuven

Joost Schymkowitz

Translational Cell & Tissue Research, Switch Laboratory (VIB-KU Leuven)

The PhD project investigates the role of tau aggregates in neurodegeneration and is part of a wider project that focusses on the discovery of novel monoclonal antibodies that can neutralize tau toxicity and spreading. Tau is the main component of the neurofibrillary tangles that are a hallmark of AD along with Alzheimer beta plaques, and a paradigm of intracellular aggregation. In the etiology of AD, the Abeta aggregation and the abnormal ...

The role of the peripheral immune system on neurodegeneration and neuroinflammation in rodent models for Parkinson’s disease KU Leuven

Veerle Baekelandt

Research Group for Neurobiology and Gene Therapy

Parkinson’s disease (PD) is the most common neurodegenerative motor disorder. No therapy can cure, stop or slow down the progression of the disease, as only symptomatic treatment strategies are available. Identifying pathogenic mechanisms underlying neurodegeneration will therefore be essential to develop a disease-modifying drug. PD is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and the ...

The lysosomal exonuclease PLD3 as an endolysosomal flux regulator: impact on neuronal homeostasis and relevance in neurodegeneration. KU Leuven

Wim Annaert

Laboratory of Membrane Trafficking (VIB-KU Leuven)

Late-onset Alzheimer’s disease (LOAD) is characterized by an unbalanced proteostasis. Dysfunctions in endolysomal transport and degradation kinetics arise at early preclinical stages and progressively worsen. Among the known LOAD risk factors, I focus on phospholipase D (PLD)-3. PLD3 is selectively expressed in neurons where it resides in late endosomes and lysosomes. It is an aspecific member of the PLD family, being an exonuclease that ...

Comprehensive characterization of structural variation andnucleotide modifications in neurodegeneration through longread sequencing and data integration. University of Antwerp

Rosa Rademakers

VIB CMN - Applied and Translational Neurogenomics

Structural variation accounts for the majority of the nucleotide diversity between humans, yet is systematically underrepresented using current technologies. We can identify about 25000 structural variants per genome with long-read nanopore sequencing, which we will perform in a discovery cohort of 200 control individuals and patients with frontotemporal dementia or Alzheimer's disease. I will optimize structural variant calling and the ...

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