Elucidation of drug leads present in the venom of the scorpion Mesobuthus eupeus for the treatment of neuropathic pain. KU Leuven
Recent studies have highlighted a key role of Nav1.8 in neuropathic pain because of its redistribution into peripheral regions of sensory nerves after injury in animal models and humans, and the behavioural changes in response to pain after antisense knockdown. Thus, expression of Nav1.8 restrictedly to primary afferent neurons offers a highly specific and effective molecular target for the treatment of neuropathic pain and blockade of its ...