The lysosomal exonuclease PLD3 as an endolysosomal flux regulator: impact on neuronal homeostasis and relevance in neurodegeneration. KU Leuven
Late-onset Alzheimer’s disease (LOAD) is characterized by an unbalanced proteostasis. Dysfunctions in endolysomal transport and degradation kinetics arise at early preclinical stages and progressively worsen. Among the known LOAD risk factors, I focus on phospholipase D (PLD)-3. PLD3 is selectively expressed in neurons where it resides in late endosomes and lysosomes. It is an aspecific member of the PLD family, being an exonuclease that ...