Walking the lines of engineering, biology and medicine: Creating 3D human neuromuscular junctions to evaluate novel therapies for neurodegenerative diseases KU Leuven
Laboratory for Neurobiology (VIB-KUÂ Leuven), Development and Regeneration, Kulak Kortrijk Campus, BioMechanics (BMe)
The aim of this multidisciplinary project is to create a new 3D human neuromuscular circuit that resembles as close as possible the human situation. Therefore, we will culture motor neurons starting from induced pluripotent stem cells (iPCS) derived from skin biopsies of patients and healthy volunteers and combine these cells with myotubes derived from human satellite cells or iPSCs. We will develop new microfluidic devices which will allow us ...