Projects
The yin and yang of neuroinflammation: in search for novel neuroprotective and regenerative molecules. KU Leuven
Study of crosstalk between beta2-adrenergic signals and the NF-κB cascade. Relevance for neuroinflammation/ neurodegeneration. Ghent University
Recent studies indicate signals derived from the beta2 adrenergic receptor (adrb2) modulate inflammation. In this study we use different in vitro and in vivo models of neuroinflammation to unravel the molecular basis of this interaction. More specifically, we want to address how beta-adrenergic signals modulate the molecular function of NF-κB, one of the crucial mediators of inflammatory reactions.
The study of alpha-synuclein pathology and related neuroinflammation in a human brain-like context: a human neurospheroid approach. University of Antwerp
IL-34 mediates a novel non-canonical function of regulatory T cells by protecting brain barriers in neuroinflammation Hasselt University
Xenotransplantation of iPSC-derived microglia to elucidate the impact of C9orf72 hexanucleotide repeat expansion on neuroinflammation and neurodegeneration. University of Antwerp
OTULIN in neuroinflammation, multiple sclerosis and Alzheimer pathology Ghent University
Inflammatory signaling pathways are subjected to tight regulation to avoid chronic inflammation and the development of inflammatory pathology. One of the proteins involved in such regulation is the deubiquitinating enzyme OTULIN. In my PhD, I aim to investigate the role of OTULIN in central
nervous system inflammation and in models of multiple sclerosis and Alzheimer pathology.
Investigation of functional immune cell-astrocyte interaction and its contribution to Neuroinflammation KU Leuven
Neurological function and dysfunction are controlled by complex biological responses involving the coordinated activities of multiple cell types in the central nervous system (CNS). A growing body of evidence points to the importance of the reciprocal communication between CNS-resident cells and the immune system for CNS physiology. Integration of the glial compartment as an active participant in neuroimmune processes is paramount. My key ...