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Targeted PDE4 inhibition to counteract neuroinflammation: a stroke of genius. Hasselt University

Ischemic stroke, meaning brain tissue loss due to a sudden blood flow occlusion, is one of the most common causes of death and disability worldwide. Current treatments are only applicable to a small subset of patients, highlighting the urgent need for more effective stroke therapies. Neuroinflammation is a major pathological event involved in the process of ischemic injury. Therefore, I aim to target this event by using a new therapy namely ...

The yin and yang of neuroinflammation: in search for novel neuroprotective and regenerative molecules. KU Leuven

Lieve Moons

Animal Physiology and Neurobiology

Acute inflammation was recently reported to enhance neurogenesis in the adult zebrafish CNS after stab injury. Based on these findings and recent data suggesting a beneficial effect of acute microglia reactivation/macrophage infiltration on RGC regenerative responses in the zebrafish retinotectal system, we hypothesize that a controlled induction and subsequent resolution of neuroinflammation largely underlies the successful regenerative ...

Study of crosstalk between beta2-adrenergic signals and the NF-U+03BAB cascade. Relevance for neuroinflammation/ neurodegeneration. Ghent University

Jan Tavernier

Department of Physiology, Department of Biochemistry, Department of Biomedical molecular biology

Recent studies indicate signals derived from the beta2 adrenergic receptor (adrb2) modulate inflammation. In this study we use different in vitro and in vivo models of neuroinflammation to unravel the molecular basis of this interaction. More specifically, we want to address how beta-adrenergic signals modulate the molecular function of NF-U+03BAB, one of the crucial mediators of inflammatory reactions.

OTULIN in neuroinflammation, multiple sclerosis and Alzheimer pathology Ghent University

Geert van Loo

Department of Biomedical molecular biology

Inflammatory signaling pathways are subjected to tight regulation to avoid chronic inflammation and the development of inflammatory pathology. One of the proteins involved in such regulation is the deubiquitinating enzyme OTULIN. In my PhD, I aim to investigate the role of OTULIN in central
nervous system inflammation and in models of multiple sclerosis and Alzheimer pathology.

Personalized prevention and halting of Alzheimer's Disease progression along the ATN axis: Targeting ApoE, neuroinflammation and lipid metabolism Hasselt University

Ilse DEWACHTER

Neurosciences, Catholic University of Leuven

Brains of AD patients are characterized by the progressive development of Amyloid (A), tau (T) and neurodegeneration (N) in the brains, or ATN axis, associated with a devastating disease, currently incurable. Interestingly, an initial phase of amyloid pathology precedes development of tau pathology and neurodegeneration, by more than a decade, providing a therapeutic window before symptoms develop. As AD is characterized by irreversible loss of ...

Xenotransplantation of genetically engineered iPSC-derived microglia and neurons to decipher the cell-type specific interplay of Progranulin and TMEM106B in neuroinflammation and neurodegeneration. University of Antwerp

Rosa Rademakers

VIB CMN - Microglia and Inflammation in Neurological Disorders (MIND) lab, VIB CMN - Applied and Translational Neurogenomics

Frontotemporal lobar degeneration (FTLD) is an early-onset form of dementia representing 10-20% of all dementia cases. It is characterized by the loss of neurons in the frontal and temporal lobes resulting in a dramatic impact on core human qualities including personality, insight and verbal communication. Aggregates of the TAR DNA-binding protein 43 (TDP-43) are the hallmark of the most common pathological subtype of FTLD (FTLD-TDP). ...

Herpesvirus-induced neuroinflammation in the peripheral nervous system (PNS) as a U+2018distantU+2019 trigger of AlzheimerU+2019s disease Ghent University

Kathlyn Laval

Department of Translational Physiology, Infectiology and Public Health

AlzheimerU+2019s disease (AD) is a neurodegenerative disorder affecting 26 million people worldwide. To date, there is no cure and current therapies are not effective in delaying progression. Thus, there is an urgent need to change the way of looking at the disease and to rethink possible therapies. Herpes simplex virus type 1 (HSV1) has recently received growing attention for its role in AD. HSV1 infects the mouth and invades peripheral ...

DNA Repair Mechanisms Protect Against the Pathological and Functional Consequences of Spinal Cord Injury and Associated Neuroinflammation Hasselt University

David WILSON

Medical School Hamburg, Neurosciences

Spinal cord injury (SCI) is a devastating neurological disorder of the central nervous system. While the primary traumatic event determines the overall severity of the SCI, the secondary neuroinflammation, associated with formation of reactive oxygen species (ROS), expands the damage, and exacerbates all deficits. ROS can react with DNA and cause damage to the genetic material, leading to cell death, senescence, or transformation. To avert these ...

Subclinical epileptic discharges in the acute phase of stroke: influence on neuroinflammation and patient outcome, and identification of associated factors Ghent University

Veerle De Herdt

Department of Head and Skin

In this research project, the prevalence of subclinical epileptic discharges in the acute phase after stroke will be determined. These discharges will also be correlated with neuroinflammatory markers, radiological parameters and patient outcome. Finally, associated factors will be identified to define a subpopulation at risk for subclinical epileptic discharges.

M2 polarization of neuroinflammation as a new approach targeting temporal lobe epilepsy University of Antwerp

Idrish Ali

Translational Neurosciences (TNW)

Epilepsy is a neurological disorder affecting about 60 million people worldwide. It is charactised by recurrent unprovoked seizures. Mesial temporal lobe epilepsy (MTLE), the most common form of focal epilepsies, is not controlled by current anti-epileptic treatements in around 1/3rd of the patients. An epileptogenic insult leads to a strong inflammatory response characterized by activation of innate brain immune cells as well as migration of ...

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