1 - 10 of 14 results
The yin and yang of neuroinflammation: in search for novel neuroprotective and regenerative molecules. KU Leuven
Study of crosstalk between beta2-adrenergic signals and the NF-U+03BAB cascade. Relevance for neuroinflammation/ neurodegeneration. Ghent University
Recent studies indicate signals derived from the beta2 adrenergic receptor (adrb2) modulate inflammation. In this study we use different in vitro and in vivo models of neuroinflammation to unravel the molecular basis of this interaction. More specifically, we want to address how beta-adrenergic signals modulate the molecular function of NF-U+03BAB, one of the crucial mediators of inflammatory reactions.
OTULIN in neuroinflammation, multiple sclerosis and Alzheimer pathology Ghent University
Inflammatory signaling pathways are subjected to tight regulation to avoid chronic inflammation and the development of inflammatory pathology. One of the proteins involved in such regulation is the deubiquitinating enzyme OTULIN. In my PhD, I aim to investigate the role of OTULIN in central
nervous system inflammation and in models of multiple sclerosis and Alzheimer pathology.
Personalized prevention and halting of Alzheimer's Disease progression along the ATN axis: Targeting ApoE, neuroinflammation and lipid metabolism Hasselt University
Xenotransplantation of genetically engineered iPSC-derived microglia and neurons to decipher the cell-type specific interplay of Progranulin and TMEM106B in neuroinflammation and neurodegeneration. University of Antwerp
Herpesvirus-induced neuroinflammation in the peripheral nervous system (PNS) as a U+2018distantU+2019 trigger of AlzheimerU+2019s disease Ghent University
AlzheimerU+2019s disease (AD) is a neurodegenerative disorder affecting 26 million people worldwide. To date, there is no cure and current therapies are not effective in delaying progression. Thus, there is an urgent need to change the way of looking at the disease and to rethink possible therapies. Herpes simplex virus type 1 (HSV1) has recently received growing attention for its role in AD. HSV1 infects the mouth and invades peripheral ...
DNA Repair Mechanisms Protect Against the Pathological and Functional Consequences of Spinal Cord Injury and Associated Neuroinflammation Hasselt University
Subclinical epileptic discharges in the acute phase of stroke: influence on neuroinflammation and patient outcome, and identification of associated factors Ghent University
In this research project, the prevalence of subclinical epileptic discharges in the acute phase after stroke will be determined. These discharges will also be correlated with neuroinflammatory markers, radiological parameters and patient outcome. Finally, associated factors will be identified to define a subpopulation at risk for subclinical epileptic discharges.