The goal of this thesis was to study silica and gold nanoparticles from synthesis to characterization to biomedical application. Nanoparticles (NPs) are typically defined as materials with at least one of its dimension in the range of 1 nm to 100 nm. In this way the NP will behave like a molecule and like bulk material. NPs have unique electronic, optical, magnetic and catalytic properties. Because of these unique properties, nanoparticles ...
Iron (Fe), one of the most abundant elements on Earth, can appear in different structural phases associated with contrasting magnetic properties, depending on temperature and pressure. The most common phase is a-Fe, which has a body-centered cubic (bcc) structure and is ferromagnetic. Another iron allotrope, y-Fe, a high temperature phase in bulk, has a face-centered cubic structure (fcc). However, this iron allotrope has been stabilized at ...
Multitasking nanoparticles for intracellular imaging and biosensing Ghent University
The goal of this project is to develop novel functional nanoparticles as advanced tools for
intracellular imaging and biosensing. The design of these nanoparticles involves the use of
semiconductor nanocrystals, or quantum dots (QDs), as bright and stable luminescent markers
encapsulated in a protective silica matrix. These QD@SiO2 nanoparticles are further functionalized with plasmonic nanocrystals, such as gold or silver ...
Influence of the morphology of core-shell nanoparticles on the mechanism of organic halide reduction University of Antwerp
Physico-chemical characterization and risk assessment of the fraction of nanoparticles in the food additive E174 (silver) in a legislative context. Hasselt University
Identification of factors affecting physicochemical fate of metallic nanoparticles released into surface waters Ghent University
The project identifies parameters affecting the fate of metallic nanoparticles released into surface waters and reveals kinetics of transformation processes occurring after such release. In addition, environmental factors affecting remobilization of adsorbed or precipitated metallic nanoparticles into surface waters are studied. Focus is also laid on developing analytical methods to quantify metallic nanoparticles in surface waters.
Research in formulation of poorly watersoluble active compounds in PLGA Nanoparticles using spray-drying technology. University of Antwerp
Utilization of magnetic nanoparticles and carbon nanotubes for the fabrication of electrochemical sensors for the determination of some important biological and pharmaceutical compounds University of Antwerp
Lignin valorization into innovative hydroxylated aromatics through a one-pot catalytic process using supported bimetallic nanoparticles boosted by the development of 2D liquid chromatography Ghent University
This project aims to valorise lignin, a renewable biopolymer from woody plants, by producing reactive bio-aromatic monomers and oligomers with a high functionality through a one-pot simultaneous reductive depolymerisation and demethylation using supported bimetallic nanoparticles. Additionally, a novel method for two dimensional liquid chromatography will be developed and the effect of genetic modification of the lignin feed will be ...
Improved intracellular delivery of upconversion nanoparticles by laser-induced vapor nanobubbles for multimodal bio-imaging applications Ghent University
Vapor nanobubble induced membrane poration will be explored as novel method for efficient delivery of upconversion nanoparticles into the cytosol of living cells. Benefits for in vivo cell tracking will be demonstrated over standard endocytic nanoparticle uptake, including improved labeling uniformity, high-throughput cell labeling, reduced toxicity, improved long term visibility and better signal quantification.