Projects
Probing local ROS distributions and calcium signaling microdomains in cardiac myocyes after myocardial infarction KU Leuven
After a heart attack some of the heart tissue has died (myocardial infarction) and the heart is left scarred. The remaining tissue and cells will grow and adapt but overall the heart pump function is weakened and the heart rhythm is also affected with sometimes deadly rhythm disturbances. This phenomenon is referred to as remodeling and better knowledge may give insights on how to slow or reverse this deleterious process and improve health. ...
Ryanodine receptor heterogeneity in cardiac myocytes in ischemic cardiomyopathy after myocardial infarction KU Leuven
Ventricular arrhythmias can be an unwanted consequence after myocardial infarction and are a major cause of mortality worldwide. A large fraction of these arrhythmias are thought to be initiated and perpetuated through a loss of a normal intracellular calcium balance, causing abnormal electrical activity and proarrhythmogenic events. In the current project, we will examine the changes in one of the key proteins that regulate the calcium ...
Mechanisms of triggers and substrate of ventricular tachycardia in the myocardial infarction border zone KU Leuven
Sudden death because of abnormal electrical activity of the heart is an important complication in patients who suffered a heart attack. The clogging of the blood vessel during an attack will leave a part of the heart damaged. The scar that replaces the lost heart tissue cannot maintain the normal heartbeat and the other cells in the heart will grow and adapt to maintain the heartbeat. Between this living tissue and the scar is a border zone. ...
Linking functional microarchitecture of the myocardial infarction borderzone to arrhythmogenesis KU Leuven
The mortality associated with a heart attack has become quite low due to better treatment during this acute event. However, life-threatening rhythm disorders often develop in the following months and years for which treatment remains limited. Providing novel insights in the underlying mechanisms is the major aim of the proposed research. The proposal builds on the power of novel research tools to investigate why the border zone around the ...
Preconditioned dental pulp stem cells: a promising candidate to repair cardiac tissue after myocardial infarction Hasselt University
The role of autophagy in lethal reperfusion injury following myocardial infarction and the effect of postconditioning in relation to adiponectin plasma levels. University of Antwerp
The study of the homing of human hematopoietic stem cells to the myocardial infarction in the SCID / NOD mouse. Ghent University
Biomaterials and nanoparticles for more efficient administration of cells and proteins in regenerative therapy after myocardial infarction KU Leuven
The aim of this project is to investigate how, after a heart attack, biomaterials and nanoparticles can ensure a more efficient administration of cells and proteins so that the regeneration becomes more efficient.
Microdomain modulation of ryanodine receptors in post-myocardial infarction remodeling of cardiac myocytes. KU Leuven
After a myocardial infarction the burden on the surviving heart tissue increases. In response, the cells grow bigger and adapt to maintain the pump function of the heart. Unfortunately, these adaptive changes are limited and the heart now has a reduced work capacity. The changes also carry unwanted consequences as the heart becomes more vulnerable to rhythm disorders. In the current project we examine the changes in one of the key proteins ...