Publications
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Analysis of Mycobacterium species for the presence of a macrolide toxin, mycolactone Institute of Tropical Medicine
Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export Flanders Institute for Biotechnology Ghent University
First report of a mycolactone-producing Mycobacterium infection in fish agriculture in Belgium [research letter] Institute of Tropical Medicine Ghent University
Mycobacterium ulcerans triggers T cell immunity followed by local and regional but not systemic immunosuppression Institute of Tropical Medicine
Buruli ulcer (BU) is a neglected infectious disease caused by Mycobacterium ulcerans, characterized by necrotic cutaneous lesions induced by the exotoxin mycolactone. Despite evidence of Th1-mediated protective immunity, M. ulcerans infection has been associated with systemic immunosuppression. We show that early during mouse infection with either mycolactone-positive or negative strains, pathogen-specific IFN-gamma-producing T cells developed ...
Differences in virulence and immune response induced in a murine model by isolates of Mycobacterium ulcerans from different geographic areas Ghent University
Buruli ulcer (BU) is the third most common mycobacterial disease in immunocompetent hosts. BU is caused by Mycobacterium ulcerans, which produces skin ulcers and necrosis at the site of infection. The principal virulence factor of M. ulcerans is a polyketide-derived macrolide named mycolactone, which has cytotoxic and immunosuppresive activities. We determined the severity of inflammation, histopathology and bacillary loads in the subcutaneous ...
Buruli ulcer: advances in understanding Mycobacterium ulcerans infection Institute of Tropical Medicine
Buruli ulcer (BU), caused by the environmental organism Mycobacterium ulcerans and characterized by necrotizing skin and bone lesions, poses important public health issues as the third most common mycobacterial infection in humans. Pathogenesis of M ulcerans is mediated by mycolactone, a necrotizing immunosuppressive toxin. First-line therapy for BU is rifampin plus streptomycin, sometimes with surgery. New insights into the pathogenesis of BU ...