Publications
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Validation of bedaquiline phenotypic drug susceptibility testing methods and breakpoints: a multilaboratory, multicountry study Institute of Tropical Medicine
Drug-resistant tuberculosis persists as a major public health concern. Alongside efficacious treatments, validated and standardized drug susceptibility testing (DST) is required to improve patient care. This multicountry, multilaboratory external quality assessment (EQA) study aimed to validate the sensitivity, specificity, and reproducibility of provisional bedaquiline MIC breakpoints and World Health Organization interim critical ...
Evaluation of the Genotype(R) MTBDRplus assay as a tool for drug resistance surveys Institute of Tropical Medicine
SETTING: A national tuberculosis (TB) drug resistance survey in Tanzania. OBJECTIVE: To compare the performance of the Genotype(R) MTBDRplus line-probe assay (LPA) on smear-positive sputum specimens with conventional culture and isoniazid (INH) plus rifampicin (RMP) drug susceptibility testing (DST). DESIGN: Mycobacterium tuberculosis isolates tested at the Tanzanian Central TB Reference Laboratory (CTRL) were submitted for quality assurance of ...
Development of simple and inexpensive tools for the control of mycobacterial diseases in a low-resource country Institute of Tropical Medicine
Efficacy and safety of a 4-drug fixed-dose combination regimen compared with separate drugs for treatment of pulmonary tuberculosis: the Study C randomized controlled trial Institute of Tropical Medicine
CONTEXT: Fixed-dose combinations (FDCs) of drugs for treatment of tuberculosis have been advocated to prevent the emergence of drug resistance. OBJECTIVE: To assess the efficacy and safety of a 4-drug FDC for the treatment of tuberculosis. DESIGN, SETTING, AND PATIENTS: The Study C trial, a parallel-group, open-label, noninferiority, randomized controlled trial conducted in 11 sites in Africa, Asia, and Latin America between 2003 and 2008. ...
Diagnosis of drug-resistant tuberculosis: reliability and rapidity of detection Institute of Tropical Medicine
From multidrug- to extensively drug-resistant tuberculosis: upward trends as seen from a 15-year nationwide study Institute of Tropical Medicine
BACKGROUND: Emergence of extensively drug-resistant tuberculosis (XDR-TB) represents an enormous challenge to Public Health globally. METHODS: Progression towards XDR-TB was investigated in Belgium, a country with a typically low TB incidence, by analyzing the magnitude, characteristics, and treatment success of multidrug-resistant tuberculosis (MDR-TB) through a population-based study from 1994 to 2008. RESULTS: Among the 174 MDR-TB patients, ...
Timing of antiretroviral therapy in Cambodian hospital after diagnosis of tuberculosis: impact of revised WHO guidelines Institute of Tropical Medicine
Rifampicin drug resistance tests for tuberculosis: challenging the gold standard Institute of Tropical Medicine
Setting:The rapid diagnosis of rifampicin resistance is hampered by reported insufficient specificity of molecular techniques for detection of rpoB mutations. Objective:To document the prevalence and prognostic value of rpoB mutations with unclear phenotypic resistance.Design:Sequencing directly from sputum of first failure or relapse patients without phenotypic selection; comparison of standard re-treatment regimen outcome by mutation. ...