Projects
Development of a Centre for Whole Genome Sequencing studies of Mycobacterium. University of Antwerp
Culture-free approaches including whole genome sequencing in support of diagnostic and transmission studies on Mycobacterium leprae. University of Antwerp
Culture-free approaches including whole genome sequencing in support of diagnostic and transmission studies on Mycobacterium leprae Institute of Tropical Medicine
Molecular Epidemiology of tuberculosis at Human-Animal interface in the pastoral areas of Ethiopia with subsequent development of improved diagnostic approach KU Leuven
Against the available diagnosis and treatment advances, tuberculosis remains a relentless disease that is one of the leading causes of death from a single infectious agent worldwide. More importantly, the highest burden of tuberculosis is attributed to low- and middle-income countries such as Ethiopia, where limited resources and high population density intersect. Since zoonotic mycobacteria have numerous host ranges that serve as ...
Using novel molecular approaches to understand the transmission dynamics of Mycobacterium leprae in the Comoros. University of Antwerp
Integrated Bovine Tuberculosis Diagnostics Approach: Bio-inspired Approaches KU Leuven
The overarching research question:
"Can we generate a proof-of-concept for improved diagnostics based on naturally prevalent biomolecules?"
More specifically, we will answer the following questions in:
WP2: "Can the heavy chain only antibodies directed against BTB in Alpacas be used as an affinity isolation/detection tool in BTB diagnostics?"
WP3: "Can the cell wall binding domains of endolysins isolated from ...
Multi Omics Data Integration to predict the M. tuberculosis Bedaquiline Resistance Phenotype from the Genotype Institute of Tropical Medicine
Currently, clinical research on the best combinations in which to use new drugs suffers from a genotype-phenotype gap: we can test for resistance in the lab (phenotype) but we can’t predict the phenotype from
mutations. Resistance testing for Bedaquiline is ...