Projects
Synthesis and biological evaluation of inhibitors of the of UvrD helicaseMycobacterium tuberculosis. KU Leuven
A diversity-oriented synthesis (DOS) approach for the functionalisation of benzo(g)(iso)quinoline--5,10-dione derivates with potential anti-plasmodial and anti-mycobacterial activity. University of Antwerp
Application of enzyme substrate analogues: from inhibitors with anti-mycobacterial properties to synthetic genetic polymers KU Leuven
Part 1:
Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis (M. tuberculosis).It is regarded as the leading cause of death from a single infectious agent, even above HIV/AIDS. Although the global tuberculosis incidence has declined marginally over the past two decades, it still affects 10 million people each year and remains out of control in several parts of Africa ...
Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitors KU Leuven
Persistent, untreatable infections pose a substantial financial and medical burden on society. Mycobacterium tuberculosis (Mtb) and BK polyomavirus (BKV) are two endemic species that have persisted for more then a century and over 60 years, respectively. Both infections present ongoing challenges to the public health. Within this thesis, novel lead compounds targeting both infections were discovered. In the first part, the thesis focussed on ...
Whole Genome Sequencing to streamline TB diagnosis, improve TB surveillance and optimize individualized TB treatment: a pragmatic trial. University of Antwerp
Structure-based design of ribonucleoside triphosphate (rNTP) analogs targeting bacterial RNA polymerases KU Leuven
Structure-based design of ribonucleoside triphosphate (rNTP) analogs targeting bacterial RNA polymerases KU Leuven
The emergence of antibiotic resistance is among the leading public health concern worldwide. While the restricted use of antibiotic is adopted as a general practice to minimize the emergence of resistant bacteria, the discovery of new drugs is of urgent need. Inhibitors targeting bacterial RNA polymerase (RNAP) are used for treating several bacterial infections. Rifampicin is used to treat infections caused by mycobacteria tuberculosis and ...
A Combined Experimental and Theoretical Approach towards Sulfenylation in the Peroxiredoxin AhpE of M. tuberculosis: Unraveling its Redox Chemistry Vrije Universiteit Brussel
The agent causing TB is Mycobacterium tuberculosis (Mtb). Mtb infect, reside and multiply in alveolar macrophages. Mtb causes the formation of granulomas, where this pathogen is exposed to ...