Projects
Consequences of Mycobacterium tuberculosis genetic diversity in the context of HIV co-infection for laboratory diagnosis of tuberculosis in Africa Institute of Tropical Medicine
1. To determine the variation and risk factors for drug-resistant tuberculosis in sub-Saharan Africa.
2. To evaluate the clinical utility of a novel molecular assay in various combinations with existing methods for diagnosis of HIV-related tuberculosis.
3. To determine the clinical predictors of mycobacteremia among HIV-infected smear- negative adults in a high prevalence HIV/TB setting in relation to the utility of ...
Development of a comprehensive platform for targeting redox homeostasis in Mycobacterium tuberculosis. University of Antwerp
Investigating drug tolerance in Mycobacterium tuberculosis Institute of Tropical Medicine
Development of a comprehensive platform for targeting redox homeostasis in Mycobacterium tuberculosis. KU Leuven
The prevalence of drug resistance in Mycobacterium tuberculosis (Mtb) calls for the legitimization of new and highly specific drug targets, focusing on unique pathways. The mycothiol ligase (MshC) and mycothione reductase (Mtr) are two components of the mycobacterial redox homeostasis that display the three key components of antibiotic drug targets; high druggability and the potential to show high specificity and essentiality for the ...
Molecular epidemiological approach to understand the emergence and spread of drug resistant Mycobacterium tuberculosis strains in Peru Institute of Tropical Medicine
Hit-to lead and lead optimization approaches in Mycobacterium tuberculosis drug-discovery. University of Antwerp
Biological evaluation of 1,3-diaryltriazenes and their mechanism of action on Mycobacterium tuberculosis. University of Antwerp
Molecular detection of multidrug resistance in Mycobacterium tuberculosis from slides and filter paper cards in middle and low-income countries Ghent University
Difficulties with drug resistance detection are often caused by the limitation of transport of samples. The main objective of this project is to investigate the feasibility to use DNA extracted from different transportation supports (sputum smear-slides, filter paper cards, and ethanol-stored samples) for the molecular detection of rifampicin and isoniazid resistance using the GenoType MTBDRplus kit.
Fight against Mycobacterium tuberculosis infection with cell wall enzymes Ghent University
IWT / SB-2014 batch of IWT /
IWT/ SB / van Schie Loes / 131545 Fight against Mycobacterium tuberculosis infection with cell wall enzymes
Background The major global health threat tuberculosis is caused by Mycobacterium tuberculosis (Mtb). Mtb has a complex cell envelope U+2013 a partially covalently linked ...