Projects
Development of a comprehensive platform for targeting redox homeostasis in Mycobacterium tuberculosis. KU Leuven
The prevalence of drug resistance in Mycobacterium tuberculosis (Mtb) calls for the legitimization of new and highly specific drug targets, focusing on unique pathways. The mycothiol ligase (MshC) and mycothione reductase (Mtr) are two components of the mycobacterial redox homeostasis that display the three key components of antibiotic drug targets; high druggability and the potential to show high specificity and essentiality for the ...
Biological evaluation of 1,3-diaryltriazenes and their mechanism of action on Mycobacterium tuberculosis. University of Antwerp
Development of novel methods to predict the drug resistance phenotype of Mycobacterium tuberculosis variants. University of Antwerp
Mycobacterium tuberculosis defence mechanisms against aggressive oxygen: signalling and protection against overoxidation Vrije Universiteit Brussel
Omics Data Integration to Predict Drug Resistance in Mycobacterium tuberculosis Vrije Universiteit Brussel
worldwide. Improved diagnosis is essential to address increasing TB
antimicrobial resistance and to assign an effective treatment regimen.
The advent of whole-genome sequencing (WGS) promises to
overcome slow, more expensive, and biohazardous assay
susceptibility testing. However WGS relies on previous
understanding of resistance mechanisms in M. ...
Role of the mycobacterial cell wall lipids, myocolic acids, in the control of ontracellular replication of mycobacterium tuberculasis bacilli Ghent University
With this aim to develop new therapeutic approaches to (drug-resistant- tuberculosis, we aim to wetermine how mycobacterial cell wall mycolic acids interfere ith the host cell function and hereby facilitate intracellular replication of the bacilli. Using mouse models, the interrelation between mycolic acids-facilitated intracellular replication, disturbed macrophage cholesterol metabolic pathways and the cholesteroid nature of mycolic acids ...