Projects
Multiscale modeling of experimental regeneration set-ups in skeletal tissue engineering KU Leuven
The aim of the thesis is to develop a multiscale model of osteochondrogenic differentiation in a bioreactor environment and other experimental set-ups typically used in skeletal tissue engineering. The state of mechanical loading around the human ulna, knee joint and growing skeletal tissue in a bioreactor is to be calculated from computational models using finite element method. Subsequently, a computer model of tissue regeneration in ...
Multiscale modeling of gas transport in plant organs. KU Leuven
Multiscale characterization and modeling of crystallization processes in natural building stones Ghent University
This project focuses on the kinetics of in-pore salt and ice crystallization in natural building stones using a combined experimental-modeling approach. In-pore crystallization is studied by time-lapse imaging using X-ray micro-tomography and cryo-scanning electron microscopy to cover the complete pore size range. A pore-scale model is developed describing the physics of crystallization at the pore-scale level.
Multiscale mathematical modeling of root growth in Arabidopsis thaliana. University of Antwerp
A multiscale understanding of the dynamics of frying-induced water loss and oil uptake in porous food matrices in relation to changes in their starch and protein components KU Leuven
Complex heat, oil and water transfers occur during food frying. Concerns over the high calorie content of fried food bring about the challenge to minimize oil uptake during the process without compromising product quality. When more moisture evaporates during frying more oil is taken up by the food, respectively. Frying wheat containing foods induces changes in their starch and protein components which affect both fat uptake and the structure ...
Development of an innovative multiscale computational model to quantitatively unravel the role of cell-matrix mechanics in angiogenesis KU Leuven
The ability of cells to migrate through a tissue in the human body is vital for many processes such as tissue development, growth and regeneration. At the same time, abnormal cell migration is observed in many diseases such as cancer. In order to discover the origin of these abnormalities and develop new treatment strategies, an improved understanding of the cell migration process and its regulation is required. Mechanics of the cell and the ...
Grain Fragmentation and Texture Development in Titanium during Plastic Deformation - A Multiscale Modelling Approach KU Leuven
Titanium and its alloys have been widely used in many fields nowadays because of their excellent mechanical, physical and biological performance, among which, the biomedical applications are using more and more commercially pure grade titanium materials as artificial joints, bone plates and dental screws etc. However, these materials suffer from their relatively low strength in comparison with other biomedical materials such as steel-based ...
Exploiting MELanoma disease comPLEXity to address European research training needs in translational cancer systems biology and cancer systems medicine. KU Leuven
Novel treatment options and associated personalised, patient-tailored therapies need to be explored and developed for highly heterogeneous and chemotherapy resistant cancers, such as malignant melanoma. This can only be achieved by industry-academia collaborations in newly emerging, innovative research disciplines such as translational cancer systems biology and systems medicine. These disciplines and the associated European training needs ...
In silico modeling of the influence of scaffold properties on the in vivo tissue regeneration response in large skeletal defects KU Leuven
Bone tissue engineering (TE) uses a combination of cells, biomaterials and growth factors for the treatment of large bone defects, meaning that we have several processes occurring at tissue, cell and intracellular levels together. In order to understand them and be able to predict their behavior, multiscale mathematical models can be used. So far, some successful results have been published, but bone TE still suffers from unpredictable and ...