Projects
Unraveling the molecular architecture of peripheral nerves- a system genetics approach. University of Antwerp
Elucidation of the molecular pathology of keratoconus and construction of a mouse model. University of Antwerp
Characterization of the distinct impact of one-eyed vision on monocular cortex: a molecular, cellular and systems level analysis of cross-modal brain plasticity in the adult mouse. University of Antwerp
NEW INSIGHTS INTO GENETICS OF PROGRESSION OF B-CELL LYMPHOMA KU Leuven
Gene therapy for cystic fibrosis in a mouse model using adeno-associated viral vectors KU Leuven
Cystic fibrosis (CF) is the most common monogenic life-threatening disease in the Caucasian population, caused by mutations in CFTR, a chloride/bicarbonate channel that regulates fluid transport across epithelium of different organs (airways, pancreas, intestine, sweat glands and vas deferens). CF affects multiple organs, but lung pathology is the major clinical manifestation. Mutations in the CFTR gene lead to an imbalance ...
Development and validation of active and passive immunotherapy targeted at protein Tau in transgenic mouse models for Alzheimer's disease KU Leuven
A mouse model of somatic cell gene delivery as a tool to identify melanoma progression and metastasis genes. KU Leuven
Characterization of the regulated secretory pathway in neurons of a mouse model for autism. KU Leuven
Autism is a severe neurodevelopmental disorder. It belongs to a group of pervasive developmental disorders with a prevalence of 0,7%. Autism spectrum disorders are diagnosed purely on clinical grounds by impairment in social interactions and communication and repetitive, stereotyped patterns of behaviour and interests. Twin and family studies indicate a strong genetic contribution to the aetiology of autism, although environmental causes are ...