Projects
Accurate attenuation correction in PET-CT and PET-MR using time-of-flight (TOF) information Ghent University
Positron emission tomography (PET) is based on the detection of pairs of photons emitted by a positron emitting radioactive tracer administered to the patient. Reconstruction algorithms process these emission data to estimate the spatial distribution of the tracer in the body. These algorithms require information on the tissue density to correct for the photon attenuation within the patient. Multi-modality PET/CT systems obtain the tissue ...
Non-invasive motion tracking for awake rat brain positron emission tomography with in vivo validation. University of Antwerp
Novel image processing methods for assessing myocardial energetics from FDG-PET/CT and 4D anatomical imaging KU Leuven
The measurement of 18F-Fluorodeoxyglucose (FDG) uptake by positron emission tomography (PET) is a validated and robust way to investigate myocardial glucose metabolism. However, the use of PET imaging for cardiac applications is challenged by:
- the low spatial resolution of the clinical PET scanners, which results in blurring and does not
allow for accurate quantification of very thin or small structures (partial volume effect, ...
Biomechanical Models of Cells during C. elegans Embryogenesis KU Leuven
The nematode C. elegans is widely used as a model organism to study embryonic development with the prospect to uncover conserved developmental mechanisms common to various animals. In spite of intensive research in this area, many observed cellular behaviors remain poorly explained, such as the reliable and nearly invariant cellular motions: How do cells find their correct positions in the embryo? Which positional cues do the cells follow? ...
Joint model-based registration and segmentation strategies for integrated quantitative analysis of cardiac MRI sequences KU Leuven
Cardiac magnetic resonance imaging (MRI) is a state-of-the-art method for non-invasive visualization and functional analysis of the heart and enables not only qualitative but also quantitative analysis. Examples are cine MRI for assessment of cardiac contraction or T1 mapping for quantitative characterization of myocardial tissue. The different images result in a large amount of data and provide complementary information to assess cardiac ...
Data-driven microstructure imaging with multi-dimensional diffusion MRI in early brain development KU Leuven
Understanding how human brain structure develops and grows before and around the time of birth is a grand challenge in neuroscience, with far reaching implications for our understanding of neuropsychiatric disorders. Diffusion MRI (dMRI) and other quantitative MRI relaxometry modalities offer a unique means to characterize neural tissue microstructure in vivo. However, analysis of multi-dimensional dMRI in neonatal and foetal data brings ...
Gas-Liquid Interface Dynamics in Non-Isothermal Sloshing: Experimental Analysis and Simplified Modeling KU Leuven
The dynamics of a gas-liquid interface stems from a synergy of forces, primarily involving inertia, viscous dissipation, gravity and capillarity. This work focuses on the latter, which arises from the surface tension at the gas-liquid interface and the interactions with the solid surface. This phenomenon impacts many industrial applications, such as coating, inkjet printing, oil recovery, microfluidics, and medical laboratory-on-a-chip ...
An integrated dynamic evaluation platform to support clinical decision making in adult spinal deformity KU Leuven
Adult spinal deformity (ASD) is a prevalent clinical condition in the elderly, causing great burden on quality of life and functionality. Although conservative treatment serves as the first line treatment, evidence on physiotherapy in ASD is lacking. This can be explained by the standard evaluation of the patient with ASD, consisting of static radiographic imaging and patient-reported outcomes, which fail to objectively assess functional ...
LINGUA - LearnIng astronomy usiNG visUAlisations in a planetarium KU Leuven
Planetariums are science centres in which the public is exposed to the fascinating world of the (night) sky. The projections on the planetarium dome allow for an immersive experience that fosters the natural interest in astronomy. Most planetariums provide also educational services and many schools organise a planetarium visit in the context of the science curriculum. The impact of these planetarium visits on learning, however, is vastly ...