Projects
Center for Molecular Water Science - Integrated Doctoral Network KU Leuven
Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & disease KU Leuven
Next-generation genetics of early-onset dementia to increase our appreciation of the molecular signatures of dementia. University of Antwerp
The development of transgene Daphnia in a molecular reconstruction of a host-parasite coevolution. KU Leuven
Morphological, molecular and functional insights into the cardiovascular complications of autosomal dominant polycystic kidney disease Ghent University
Autosomal dominant polycystic kidney disease (ADPKD) occurs upon mutations in either the PKD1 or PKD2 gene and represents the most common monogenetic disease (incidence 1:500-1:1000). Frequent and dire complications of APDKD are cardiovascular anomalies, such as intracranial aneurysms, which upon rupture are life-threatening. Here, I intend to further exploit a CRISPR/Cas9-mediated animal model for ADPKD to obtain morphological, molecular and ...
Bcl-2/Bcl-XL proteins as modulators of calcium signaling through IP3 receptors: from novel molecular mechanisms to implications for therapeutics KU Leuven
Molecular self-assembly under 2D lateral nanoconfinement: Capabilities and prospects KU Leuven
Molecular self-assembly is omnipresent. Think about the DNA molecules in your body or soap dissolving fat. However, fundamental knowledge about the early self-assembly stages is limited and hinders controlling the process at will, sought after in numerous fields of applications. To that end, confinement of self-assembly has emerged as a strategy to obtain more insight into the early stages. Our group has developed a two-dimensional ...
Studying the Early Stage of Zeolite Synthesis using Molecular Simulations Ghent University
Zeolites are extensively used in chemical industry as shape-selective catalysts and adsorbents in
novel sustainable technologies. Despite their importance, the rational design of new zeolites
toward specific applications is still very challenging: 218 zeolite framework topologies were
synthesized of which only a small fraction is used at large in industry. Still, millions of hypothetical
zeolites ...
Efficient determination of free energy for large molecular systems with constraints Ghent University
Constraining degrees of freedom in molecular simulations may enhance the convergence of combined classical and quantum descriptions. This project will set a theoretical foundation for calculating the free energy associated with these constraints. Efficient algorithms will be developed to limit the computational cost, such that large molecular systems with applications in biochemistry and/or material science can be studied.