Functional analysis of key molecules that control the molecular identity and preserve the health of the articular chondrocytes KU Leuven
Osteoarthritis is the most common chronic joint disease with enormous societal costs. Structure and function of the joints are gradually affected, leading to pain and disability. No drug strategies are available that can stop the progression disease. A key step in the disease process is that the healthy human articular chondrocytes lose their molecular identity and alter their gene expression program thereby developing an auto-destructive ...