Infrastructure
When size matters: a platform to study molecular interactions and multimerisation (SIZEMAT) KU Leuven
A system that offers a choice of resolving the samples according to hydrodynamic volume using either size-exclusion chromatography or field-flow fractionation with an online multi-detector system including multi-angle light scattering, dynamic light scattering, UVvisible light absorption, refractometry, and the detection of fluorescence spectra. The requested instrument allows to separate a complex molecular sample according to the size of the comprising molecules, followed by immediate inline characterisation of the molecular weight, shape,
concentration and binding to ...
Platform for Microscopy and Molecular Analysis of Marine Invertebrates Ghent University
These microscopic and molecular instruments are essential to understand the morphology and genetic characteristics of marine invertebrates. They are mostly used to understand the diversity of invertebrates in the seabed and their role in the functioning of marine ecosystems.
Towards a versatile photoelectron spectroscope for in situ interfacial molecular studies in materials science (XPS) Vrije Universiteit Brussel
in situ molecular interface analysis in a wide field of materials science. As such, an ultraviolet source will be added, enabling first nm top surface analysis and giving insights in valence band levels and orbital hybridisation.
Furthermore, a gas cluster ion sputter source is considered into this proposal, in order to create well-controlled depth profiles of ...
Studying PHYsiology with NeXt generation Molecular imaging: SPHYNX (SPHYNX) Ghent University
Existing Total Body PET scanners are very expensive. In this project, we ensure that this fast technique can also provide high patient throughput. Using the latest monolithic detector technology, we propose a new design, departing from the classical positioning of the patient on a bed. We propose an upright scanner (similar to mm-wave scanners at airports or flat X-ray) using TOF technology. This optimizes the detector area and avoids time-consuming positioning of the patient. The purpose of this scanner is to study physiology in plants, veterinary animals and humans. The new design has a ...
Nuclear Magnetic Resonance Spectroscopy Platform for Molecular Water Research (NMRCORE) KU Leuven
NMRCORE is a convergent research node operating 3 medium to high field research NMR spectrometers, optimized to investigate different states of water upon confinement in nanoscopic cavities. This IRI proposal aims to allow us to operate as a research infrastructure hub of CMWS. Within the local research program, we envisage the design of a dedicated NMR platform suited for in situ access to all facets of structure, dynamics and interface behavior of water confined in porous hosts. In situ multidiagnostic NMR techniques will be developed and especially an NMR-dielectric coupled cell is ...
Enabling Nuclear Magnetic Resonance (NMR) spectroscopy for the characterization of small to medium-sized organic molecules at VUB (NMR) Vrije Universiteit Brussel
The DUBBLE Beam Lines at the ESRF: Extremely brilliant X-rays for revealing the structure and function of atoms, molecules and materials (DUBBLE) KU Leuven
Synchrotron X-rays are produced when charged particles circulate in a storage ring close to the speed of light and are much more intense compared to the X-rays used for example in hospitals. By studying the interaction of a synchrotron X-ray beam with matter, the matter structure is revealed down to the atomic and molecular scale. A synchrotron can be imagined as a giant microscope that can ook at the inside of non-living and living matter down to the atomic level without damaging it. This project finances research at DUBBLE, the Dutch-Flemish research stations attached to the European ...
Flanders BioImaging: towards an integrated, translational and multimodal imaging platform from molecule to man (FBI) KU Leuven
Imaging has become a key technology in life sciences and clinical research. As an ESFRI project, Flanders BioImaging (FBI) historically consists of two main multisite nodes: FLAMINGO (Flanders Molecular Imaging Organisation) and LIMBO (Light Microscopy BioImaging Operations), that were both successfully evaluated in the EU EuroBioImaging (EuBI) project at its Interim operation (ERIC status now). The primary aim of this project is to anchor both consortia in order to provide international researchers access to an integrated high-capacity network of state-of-the-art imaging infrastructure ...
Modular high-end mass spectrometer for ultra-sensitive quantification and imaging of small organic molecules in cross-health research (MSSMALL-XH) KU Leuven
The current high-throughput multi-omics technologies, complemented with revolutionary micro- and nanoscopic imaging tools, offer amazing opportunities for holistic investigation and pathophysiologic understanding of diseases in both man and animals. However, the accurate and specific quantification of small organic molecules currently faces two major challenges: 1) the increasing availability of microsamples from biological origin having ever smaller sizes requires the increasing need for ultrasensitive quantification up to sub-pg/g (mL) level; 2) the unmet need for imaging and spatial ...