Projects
"Silent" voltage-gated K+ channel subunits: analysis of the molecular determinants of modulatory properties and electrically silent behavior and elucidation of the physiological role. University of Antwerp
Molecular mechanism and function of modulatory subunits of Kv channels. University of Antwerp
Molecular mechanisms of the interaction between neurotoxins and potassium and sodium channels. University of Antwerp
Molecular mechanisms of voltage-dependent gating in potassium channels. University of Antwerp
Molecular structure-function analysis of a novel class of K-channel blocking scorpion toxins. University of Antwerp
An integrated molecular, functional and structural characterization of the determinants, underlying the multi-domain complexes between IP3 receptors and anti-apoptotic Bcl-2 and Bcl-Xl proteins KU Leuven
Intracellular Ca2+ signals play a critical role in multiple cellular processes, including proliferation and apoptosis. A key regulator of Ca2+–signaling is the inositol 1, 4, 5 trisphosphate (IP3) receptor (IP3R), which is the main intracellular Ca2+–release channel. The anti-apoptotic members of the B-cell lymphoma 2 (Bcl-2) family of proteins, Bcl-2 and Bcl-Xl, have emerged as distinct factors that critically control IP3R activity. Bcl-2 ...
Molecular basis for the potency and selectivity of DNDI-6690, a promising lead for the development of novel anti-leishmanial drugs. University of Antwerp
Catheter-based sensors for the intestinal detection of molecular biomarkers in the context of functional bowel disorders KU Leuven
Food-induced abdominal symptoms are extremely common and remain poorly understood. In a recent Belgian survey, 18% of the adults reported symptoms of the irritable bowel syndrome (IBS), and half of them identified certain foods as triggers of their symptoms. Histamine and serotonin are two important signaling molecules in the gastrointestinal mucosa, thought to be involved in adverse reactions to food. However, it has been notoriously ...
The molecular and structural basis of pro- and anti-inflammatory signalling assemblies mediated by IL-27 and IL-35. Ghent University
Mammalian cellular development and regulation of the immune system crucially depend on appropriate signalling pathways initiated by dedicated cytokine-receptor assemblies at the cellsurface. The downside of such a key physiological activity is that native and mutant forms of cytokines and their receptors are often pivotal to the initiation and progression of inflammatory disorders, cellular malignancies and cancer. Interleukin-35 (IL-35) and ...