Projects
SAFIR-ABC10: molecular screening for precision medicine in advanced biliary cancers KU Leuven
Molecular screening for precision medicine in advanced biliary cancers intended for patients with Advanced Biliary Tract Cancer naïve for first-line systemic treatment, is a program including 4 protocols, detailed in the research project section (SAFIR-ABC10).
Metabolomics-driven Molecular Source Analysis for personalized medicine in children Ghent University
While recent advent empowered the new reality of holistic metabolic phenotyping, we are currently still unable to accurately
determine the source(s) of the underlying metabolites. This is undoubtedly the main stumbling block in inferring causality to new
biomarkers for disease prevention, prediction, and prognosis, particularly given the rapidly increasing burden of metabolic diseases.
At the same time, conventional ...
Cell-free nucleic acid profiling in diffuse large B-cell lymphoma: a molecular guidance to precision medicine Ghent University
Diffuse large B-cell lymphoma (DLBCL) is the most common histological subtype of non-Hodgkin’s lymphomas. DLBCL is an aggressive malignancy that displays major heterogeneity in terms of morphology, genetics and biological behavior. While complete remission is obtained in 70% of cases, patients with refractory or relapsed disease have a poor prognosis. Current classifications fail to identify high-risk subgroups and improve their outcomes. In ...
Cell-free nucleic acid profiling in diffuse large B-cell lymphoma: a molecular guidance to precision medicine Ghent University
Total RNA sequencing is performed on matched tissue and plasma samples within a human DLBCL cohort to identify (circulating) biomarkers, linked to phenotype, response, and prognosis. Complementary, cell-free RNA (cfRNA) is explored in a patient-derived DLBCL xenograft model, enabling step-by-step dissection of the circulating transcriptome in tumor-, immune-, and stromal cellderived fractions. Lastly, a multi-omics analysis will compare cfRNA ...
Development of treatment intensification strategies for high-risk prostate cancer based on clinicopathological and molecular modeling, with the aim of delivering precision medicine to the individual patient. KU Leuven
Prostate cancer (PCa) is a tremendous health problem that affects
about 1 in 8 men in developed countries. High-risk PCa covers 20%
of new diagnoses and accounts for more than two-thirds of all deaths
from prostate cancer. Better risk stratification within high-risk PCa
can help determine who are suitable candidates for de-escalation
versus intensification of therapy, potentially affecting tens of
thousands of ...
Translational SYStemics: Personalised Medicine at the Interface of Translational Research and Systems Medicine KU Leuven
TranSYS will recruit 15 ESRs to highly skilled jobs in the new area of Systems Health developing tools and approaches to exploit large and complex datasets, to advance Precision (Personalised) Medicine in several disease areas. The training programme and experience of different international research environments cuts across traditional data and life sciences silos. The emphasis on translational research will support new collaborations ...
Inherited cardiac arrhythmias: identification of novel genes and development of a new diagnostic tool for translating genetic diagnosis into precision medicine. University of Antwerp
To strengthen the R&D capacities of the Institute of Tropical Medicine Alexander von Humboldt (Peru) to deliver strategies and/or tools for diagnosis, surveillance and control of infectious diseases. Institute of Tropical Medicine
PRISMO: Precision Medicine through Integrated Spatial Multi-Omics KU Leuven
In Flanders, biotech accounts for ~5% of employment and ~10% of industry is related to bioeconomy. An important part of this focuses on personalized medicine, where several Flemish top companies are global players in the field of molecular diagnostics. The recent developments in molecular and digital pathology within this consortium offer unprecedented opportunities to safeguard and even significantly expand the pioneering role of Flanders in ...