Projects
Endoplasmic reticulum and mitochondria: common drivers of human β cell and neuronal fate KU Leuven
Diabetes and brain disorders appear at first glance to be completely different diseases. However, human
genetics has unveiled some severe forms of diabetes in babies that are associated with abnormal brain
development, including small brain size and epilepsy. Intriguingly, the mutations causing these diseases hit
genes with a role in two critical organelles: the endoplasmic reticulum and mitochondria, which together control ...
Cadmium-induced responses in Arabidopsis thaliana: oxidative stress related to the effects at the mitochondrial level Hasselt University
Assessment of mitochondrial dysfunction at the basis of α-spectrinopathies. University of Antwerp
VitaminK2 as a mitochondrial electron carrier to improve Parkinson related deficiency. KU Leuven
Parkinson’s disease is the second most common neurodegerative disease, yet effective therapies do not exist. In many cases of Parkinson’s disease, a defect at the level energy generating mitochondria within cells is suspected, but effective methodologies to improve mitochondrial function are lacking. Using sick fruit flies that also harbor features of Parkinson’s disease, we find that vitamin K2 is necessary and sufficient to increase energy ...
Mitochondrial and endoplasmic reticulum stress in oocytes and embryos as treatment targets for infertile patients with metabolic diseases. University of Antwerp
Development of spectrally and polarization resolved high resolution second harmonic imaging for studying microtubules and mitochondrial transport Hasselt University
Mitochondrial abnormalities in critical illness: role in organ failure and mortality, underlying mechanisms and therapeutic perspectives. KU Leuven
Linking mitochondrial and telomere dysfunction in newborn tissues: TP53, SIRT1 and PPARGC1 alpha as a central hub? Hasselt University
The origins of mitochondrial DNA mosaicism in early human development Vrije Universiteit Brussel
were themselves mosaics. Also, there are in the ...