Endothelial mitochondria: enigmatic function and potential target for tumor anti-angiogenesis? KU Leuven
Blood vessel formation (angiogenesis) promotes tumor growth and metastasis. Current antiangiogenic therapies target endothelial growth factors, but suffer from limited efficacy. Also, since tumor vessels are structurally and functionally abnormal (which impairs perfusion), pruning them by anti-angiogenic therapy may create a more hostile nutrient-deprived milieu, promoting cancer cell escape and dissemination. A novel paradigm is to ...