Projects
OOCARE: Caring for the oocyte under maternal metabolic stress by targeting the mitochondria. University of Antwerp
Mitochondria as effectors and targets of cardiac remodeling in heart failure. KU Leuven
Investigation of the molecular mechanism by which iron availability in the mitochondria affect tolerance towards the anti fungal drug fluconazole in the human fungal pathogen Candida albicans KU Leuven
Regulatory Roles of Mitochondria and Metabolism in Neurogenesis KU Leuven
Neurogenesis is a key event of neural development, by which neural stem/progenitor cells (NSPC) stop self-renewing and dividing, to convert to postmitotic neurons. The delicate balance between self-renewal and differentiation of NSPC is controlled by intrinsic and extrinsic cues, in particular transcription factors and morphogen signals (Bonnefont and Vanderhaeghen, 2021; Villalba et al., 2020)). On the other hand, recent evidence have ...
Role of the endoplasmic reticulum and of mitochondria in the Ca2+ metabolism of motor neurons. KU Leuven
Master regulators in Parkinson's Disease: PLA2G6 in lipid metabolism, mitochondria and synaptic transmission. KU Leuven
This doctoral project is being carried out in the neuronal communication lab and wants to do research on master regulators in Parkinson's disease: research of PLA2G6 in lipid metabolism, mitochondria and synaptic transmission.
Live imaging of neurons and mitochondria in the human enteric nervous system to assess Parkinson’s disease related neurodegeneration KU Leuven
Neurodegenerative disorders, have a large impact on social and economic level; they affect quality of life to a large extent and create high financial burden for patients. Until now the only diagnosis for most of the neurodegenerative diseases is based on clinical symptoms, which occur when the disease is already advanced. Thus, available therapy for neurodegenerative disorders is unfortunately purely symptomatic. Therefore apart from ...
Mitochondrial DNA content in cardiovascular ageing and disease: a population study. KU Leuven
A major burden of modern society is the progressive increase in age-associated diseases such as heart failure (HF). The genetic and environmental drivers of left ventricular (LV) dysfunction progression remain to be elucidated. LV dysfunction is associated with changes in cardiac energy metabolism. Mitochondria play a central role in a variety of cardiac cell functions. The mitochondrial DNA (mtDNA) content correlates with the size and number ...