Long non-coding RNAs as modulators of protein synthesis rewiring in cancer KU Leuven
An increasing body of evidence indicates that oncogenic signalling enhances protein synthesis in both the cytosol and mitochondria and that this increase is essential to cancer cell survival. Targeting translational rewiring may therefore offer novel therapeutic opportunities. However, given its essential role in normal cells, modulating translation in a cancer-cell specific manner remains a major challenge. LncRNA (Long non-coding RNA) ...