Projects
Linking neurodevelopmental disorders and mitochondria in human neurons KU Leuven
OOCARE: Caring for the oocyte under maternal metabolic stress by targeting the mitochondria. University of Antwerp
Investigation of the molecular mechanism by which iron availability in the mitochondria affect tolerance towards the anti fungal drug fluconazole in the human fungal pathogen Candida albicans KU Leuven
'The role of ATP13A2 in mitochondrial functionality' KU Leuven
ATP13A2 is a late endolysosomal P5B-type transport ATPase that exports polyamines from the late endolysosome to the cytosol. Loss-of-function mutations in this transporter lead to a range of neurodegenerative disorders, which are all characterized by increased oxidative stress and a flawed mitochondrial-lysosomal axis at the cellular level. In addition, overexpression of ATP13A2 in cell models has been reported to provide protection against ...
The role of peroxisomes in hepatocytes and pancreatic Beta-cells in mouse. Relationship of peroxisomes with mitochondrie KU Leuven
Peroxisomes are plastic organelles, present in almost all eukaryotic cells, which play an essential role in intermediary lipid metabolism. Inherited diseases with defects in peroxisomal function give rise to multiple organ defects which have been mimicked in mouse models for these diseases. However, their particular function in different cell types and tissues remains largely obscure. In this thesis we investigated the consequences of ...
Parkin-mediated mitochondrial quality control: molecular mechanisms and therapeutic targets. KU Leuven
A star is born: TBMIM5 as a novel Ca2+ channel at the inner mitochondrial membrane KU Leuven
Calcium transfer between the endoplasmic reticulum, theh major intracellular calcium-storage organelle, and the mitochondria critally control cell survival and death process in health and disease (Krols M, Bultynck G, janssens A, J cell Biol, 2016). This process is modulated by several proto-oncogenes and tumor suppressors (Bittermieux M, Parys JP, Pinton P, Bultynck G, BBA-Mol Cell Res, 2016).
In this project we aim to investigate ...