Parkinson’s disease (PD) is a devastating, currently incurable brain disorder. In PD, specific nerve cells gradually die, causing tremor, slowness of movement, falls, dementia and many other problems. Why these nerve cells die, is not well understood. However, in rare familial cases PD is caused by genetic mutations that disrupt the function of the protein Parkin. Recently, it was discovered that Parkin is crucial to maintain a healthy pool ...
Mitochondria take centre stage: pathways to reduced oocyte quality and opportunities for curative strategies under maternal metabolic stress conditions. University of Antwerp
Cells of all living organisms are equipped with complex and interconnected signal transduction pathways that form a network enabling them to make appropriate changes in cell growth and metabolism in response to environmental changes. Studies have shown that the nutrient-induced signaling pathways in yeast are at the origin of the more sophisticated pathways found in higher eukaryotes. In addition, recent data indicated that inter-organelle ...
Study of the role of mitochondria during angiogenesis: can they provide a novel angiogenic target? KU Leuven
Role of the endoplasmic reticulum and of mitochondria in the Ca2+ metabolism of motor neurons. KU Leuven
Master regulators in Parkinson's Disease: PLA2G6 in lipid metabolism, mitochondria and synaptic transmission. KU Leuven
This doctoral project is being carried out in the neuronal communication lab and wants to do research on master regulators in Parkinson's disease: research of PLA2G6 in lipid metabolism, mitochondria and synaptic transmission.
Live imaging of neurons and mitochondria in the human enteric nervous system to assess Parkinson’s disease related neurodegeneration KU Leuven
Neurodegenerative disorders, have a large impact on social and economic level; they affect quality of life to a large extent and create high financial burden for patients. Until now the only diagnosis for most of the neurodegenerative diseases is based on clinical symptoms, which occur when the disease is already advanced. Thus, available therapy for neurodegenerative disorders is unfortunately purely symptomatic. Therefore apart from ...