A congenital neutrophil defect syndrome associated with mutations in VPS45. Vrije Universiteit Brussel
BACKGROUND: Neutrophils are the predominant phagocytes that provide protection against bacterial and fungal infections. Genetically determined neutrophil disorders confer a predisposition to severe infections and reveal novel mechanisms that control vesicular trafficking, hematopoiesis, and innate immunity.
METHODS: We clinically evaluated seven children from five families who had neutropenia, neutrophil dysfunction, bone marrow ...
METHODS: We clinically evaluated seven children from five families who had neutropenia, neutrophil dysfunction, bone marrow ...