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The next generation of transmission electron microscopy: from biomedicine to nanomaterials. A state-of-the art electron microscopy system for cryo-EM and correlative light and electron microscopy Hasselt University

Ivo LAMBRICHTS
Cardio & organ systems
This application was submitted by a consortium from different research institutes at Hasselt University in order to reinforce their research lines, to strengthen collaborations within Hasselt University and with external partners. This state-ofthe- art infrastructure will enable us to become important (international) players in the field of cryo-EM/CLEM since such infrastructure has only limited presence in Flanders and Belgium. The requested ...

Novel microscope designs for fast and highly adaptable fluorescence microscopy. KU Leuven

Wim Vandenberg
Biochemistry, Molecular and Structural Biology
Due to its high sensitivity and specificity, fluorescence microscopy has been a workhorse technique in (bio-)chemical and medical research for several decades. In recent years, thanks to advances in labeling chemistry, the problems to which this technique can be applied have been strongly diversified. However, the application of these new technologies in 3D rather than 2D microscopy has been limited, at least in part due to a lack ...

Research in the field of the advanced biomedical microscopic imaging: "Towards medical cytomics. Paving the way with nextgeneration microscopy". University of Antwerp

Winnok De Vos
Laboratory of cell biology and histology
The techniques for monitoring and manipulating cells have reached a level of maturity that allows them to be implemented in high-level biological research. The promotor wants to grasp this momentum and raise the standard in modern microscopy technology while connecting cellular phenotypes with disease development.From a biological perspective, it is the goal to elucidate the mechanisms underlying cellular dysfunction in the context of genetic ...

AQ²UABIT – Advanced Qualitative and QUantitative surface Analysis of BITuminous binders using laser scanning confocal microscopy. University of Antwerp

Wim Van den bergh
Energy and Materials in Infrastructure and Buildings (EMIB)
In this project, an innovative methodology is developed by using Laser Scanning Confocal Microscope (LSCM) to investigate the behaviour of bituminous binders and mortar under specific physical and mechanical conditions including the impact of several additives. Bitumen, an oil derivate, is an important binder used in asphalt mixtures, roofing materials and emulsions. Regarding the circular economy, a higher recycling rate and increased service ...

Advanced Centre for Advanced Microscopy (ACAM). University of Antwerp

Winnok De Vos, Jean-Pierre Timmermans
Laboratory of cell biology and histology
The Antwerp Centre for Advanced Microscopy (ACAM) provides high-end service for visualizing biological samples from the nano- to the mesoscale. Its mission is to be the go-to hub for demanding microscopy-oriented work and to exploit its quantitative imaging expertise to foster research excellence at the University of Antwerp. To do so, ACAM assists with project planning, sample preparation, microscope selection and use, image analysis and ...

Nanoscale imaging of magnetic structures using scanning transmission electron microscopy (NanoMagSTEM). University of Antwerp

Johan Verbeeck
Electron microscopy for materials research (EMAT)
Modern society relies on materials which exhibits or are influenced by magnetic fields, such as functional materials used in electronic devices. In the last decades the performance of such devices have been greatly improved though miniaturization, however at some point the size of the these devices cannot be reduced further due to physical limits. To continue the advances in electronics, new materials with novel properties must be utilized. This ...

INFLUXO. A fluidic module for high-throughput microscopy of intact organoids. University of Antwerp

Winnok De Vos
Product development, Vision lab, Laboratory of cell biology and histology
Modern cell and developmental biology increasingly rely on 3D cell culture models such as organoids. However, the inability to characterize these specimens at the cellular level with high throughput hampers their integration in an industrial setting. To address this bottleneck, we have developed a module for imaging organoids in flow, based on a transparent agarose fluidic chip that enables efficient and consistent 3D recordings with ...

Polarization-resolved interferometric scattering microscopy Ghent University

Alberto Curto
Department of Information technology

In this project, we will build an interferometric scattering microscope with polarization resolution. Interferometric scattering microscopy is a recent technique that exploits the interference between scattered light from a small object and reflected light from a substrate to create contrast for samples as small as a single protein. We will apply the microscope to image and characterize the morphology of nanoscale objects of interest in the ...

Exploring excited state structural dynamics of fluorescent proteins by using X-ray free electron laser (XFEL) towards advancement of cutting‐edge microscopy KU Leuven

Hideaki Mizuno
Molecular Imaging and Photonics, Quantum Chemistry and Physical Chemistry, Biochemistry, Molecular and Structural Biology
Fluorescent proteins (FPs) have become a widely opted choice for protein labelling in living specimen. Some FPs show unique photoswitching properties (psFPs) with which advanced microscopic techniques such as super-resolution microscopy have been developed. Optimizing the photoswitching properties is crucial for further advancement of the microscopic technologies, and knowledge of molecular bases behind the photoswitching reactions is ...

Laser bench for laser scanning confocal microscopy Ghent University

Kevin Braeckmans
Department of Pharmaceutics

Confocal laser scanning microscopy is a widespread technique in the life sciences to record high-quality images of biological specimen. Laser illumination is used to excite fluorescent markers in biological samples. In this project budget is requested to replace the laser illumination system of a heavily used confocal microscope, as it is getting near the end of its lifetime.