Upregulation of microRNAs to redirect fusion-negative rhabdomyosarcoma towards a myogenic phenotype KU Leuven
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric population, and fusion-negative RMS (FN-RMS) is the most common subtype. Current murine models fail to recapitulate the features observed in patients. At the same time, currently used therapies are poorly tumor-specific and fail to tackle the molecular machinery underlying the tumorigenicity and uncontrolled proliferation of RMS. In this PhD tenure work, we first ...