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Identification of pan-cancer and tumor-specific methylation based biomarkers and development of bioinformatics infrastructure for a novel multiplex methylation assay. University of Antwerp

Guy Van Camp
Medical Genetics (MEDGEN), Center for Oncological Research (CORE), Radboud Universitary Medical Centre, Human molecular genetics
With an estimated 8.8 million deaths yearly, the cancer burden weighs heavily on populations globally. Early detection of cancer is one of the key aspects that results in improved patient prognosis. In this respect, the analysis of circulating tumor DNA in plasma is potentially a major enhancement over currently used imaging, immunochemincal or histopathological methods. Highly sensitive and specific biomarkers for the most common types of ...

Methylation in situ hybridization: visualization of methylation patterns using UPSAS Ghent University

Daisy Flamez
Department of Mathematical Modelling, Statistics and Bio-informatics

MISH kan worden toegepast voor de diagnose van prostaatkanker in kleine biopten of in cytologiemonsters van neoplastische cellen in de urine van patiënten. Momenteel is onderzoek en diagnose van methylatiemarkers een zeer duur proces, waarvan de prijs kan worden verlaagd door MISH (er is bijvoorbeeld geen DNA-extractie vereist); MIVH kan ook worden geautomatiseerd voor analyses met hoge doorvoer. MIVH kan daarom een beter alternatief bieden ...

Impact of meternal diet before and during pregnancy on DNA methylation status in mother and child influencin the child's risk for obesity KU Leuven

Lode Godderis
Environment and Health, Woman and Child

Parental nutrition before conception, maternal nutrition during pregnancy,and infant nutrition in the early postnatal period (lactation) can program the infant and affect its future health. One of the underlying mechanisms responsible for metabolic programming are epigenetic modifications, such as DNA methylation. The aim is to determine the effect of dietary (methionine, folate, betaine, and choline) and supplemental (folic acid) intake of ...

Unravelling the impact of peroxisomal lipid biology on H3K79 methylation and osteoarthritis. KU Leuven

Silvia Monteagudo
Skeletal Biology and Engineering Research Center

In osteoarthritis (OA), the most common joint disease that still lacks a disease-modifying therapy, methylation of lysine 79 at histone 3 (H3K79me) in articular cartilage is reduced. Evidence showed that maintaining H3K79me is crucial to protect against OA. Yet, mechanisms that control H3K79me remain largely elusive. My project aims to address this knowledge gap. During my PhD, I successfully performed an advanced high-content microscopy ...

Wrapping up AD - Targeting myelination by editing DNA methylation Hasselt University

Tim VANMIERLO
Neurosciences
Alzheimer's Disease (AD) is the most common form of dementia, characterized by cognitive impairment such as memory loss. Despite the significant amount of research in the field, there is still no effective therapy yet. Recently, literature has shown that the myelin sheath, the protective and insulating cover of the nerve cells, is partly damaged in AD patients, eventually contributing to the neurodegenerative facet of the disease. In this ...

Uncovering regulators of H3K79 methylation in cartilage to identify targets for osteoarthritis therapy KU Leuven

Silvia Monteagudo
Skeletal Biology and Engineering Research Center

Osteoarthritis (OA), the most common chronic joint disease, is characterized by progressive damage to the articular cartilage, remodelling of the joint-associated bone, and inflammation. Current OA treatments are limited to pain relief, physiotherapy, or joint replacement surgery in severe cases, yet drugs that stop the disease progression are lacking. DOT1L is an enzyme that chemically modifies an amino-acid (Lysine at position 79) in the ...

DNA methylation markers to predict treatment success of biologicals in Crohn’s disease. Ghent University

Dirk Elewaut
Department of Internal Medicine and Pediatrics, Department of Head and Skin

In many immune-mediated diseases such as Crohn’s disease and rheumatoid arthritis the immune system requires suppression. This is where biological therapy comes in, such as the administration of therapeutic antibodies targeting inflammatory proteins or blocking the activity/trafficking of immune cells. However, treatment success is variable and there are no biomarkers capable of predicting clinical response, causing unnecessary suffering to ...

Detection of somatic mutations and disease-defining methylation patterns in brain tissue and cerebrospinal fluid of patients with non-acquired focal epilepsy Ghent University

Björn Menten
Department of Biomolecular Medicine

The majority of non-acquired focal epilepsies (NAFE) have a presumed genetic etiology. However, the current yield of diagnostic genetic testing in affected patients is very low. This diagnostic gap is an important barrier to the broader use of gene-targeted therapies. Increasing evidence from resected brain tissue of individuals with NAFE points towards an important role of pathogenic somatic variants and methylation abnormalities. Most NAFE ...

SulfoMet: Unravelling biological roles of epigenetic DNA methylation in the model archaeon Sulfolobus acidocaldarius Vrije Universiteit Brussel

Eveline Peeters
Department of Bio-engineering Sciences
Methylation of genomic DNA is a universal epigenetic mechanism
that governs phenotypic diversity, developmental processes and
stress response. In contrast to eukaryotes and bacteria, very little is
known about the biological roles of DNA methylation in archaea,
which constitute a distinct phylogenetic group. In the
thermoacidophilic model archaeon Sulfolobus acidocaldarius, the
widespread occurrence of 6-mA ...

Detection of somatic mutations and disease-defining methylation patterns in brain tissue and cerebrospinal fluid of patients with non-acquired focal epilepsy. University of Antwerp

Sarah Weckhuysen
Ghent University, VIB CMN - Applied and Translational Neurogenomics
Genetics is known to play a major role in patients with non-acquired epilepsy, and a genetic diagnosis enables more targeted treatment choices. However, two thirds of patients remain without a definitive genetic diagnosis. Studies ofresected brain tissue of individuals with focal epilepsy point towards an important role of pathogenic somatic variants and methylation abnormalities. Most epilepsy patients however do not undergo brain surgery, and ...